Forgotten. Ignored. Misunderstood. These are some of the words patients with rare immune-related diseases use to describe how their condition affects their lives. The Centre for Personalised Immunology aims to help these people living with an immune disease by finding the answers to help diagnose and treat their condition. Lupus and immunodeficiency are the diseases we are investigating in the hope of finding better treatments.
Discover how we can help you as an individual. Diagnosis of immune-related diseases is difficult because often the signs and symptoms a person experiences overlap with other illnesses. This leads to delays in diagnosis with treatments that only alleviate symptoms. Generally, medical treatments are designed to treat the average person using a "one-size-fits-all-approach". While this may work for some, for many others, treatments are ineffective.
Our objective is to understand the mechanism of immune diseases by identifying changes in your genome (your entire DNA sequence) that is causing or contributing to your immune disease. Genetically, humans are nearly 99.9% similar. But the human genome is made up of 3 billion base pairs, which means there are approximately 4-5 million locations where genetic differences occur. Some of these gene variants are common in the population, whilst others are rare. Many of these variants have no affect on your health, however others do. Some might affect your response to certain medical treatments or cause disease by disrupting a gene(s) normal function. Discovery of these variants and understanding the role they play in immune diseases will enable us to provide a diagnosis ‘personalised’ to you and to make treatments more effective.
Read more about How It Works.