Associate Investigators

Professor Xiang-yang Huang 黄向阳

Department of Rheumatology, West China Hospital / West China School of Medicine, Sichuan University | No. 37 GuoXue Xiang, Chengdu city, Sichuan, 610041, P.R. China
四川大学华西医院风湿免疫科, 教授(主任医师), 博士(MD, Ph.D), 硕士生导师 | 四川大学华西医院风湿免疫科(成都市国学巷37号)

  • Member of The Youth Working Committee of Chinese Medical Association and Chinese Rheumatology Association.
  • Reviewer of National Natural Science Foundation of China.
  • Member of The Physician Assessment Expert Committee.
  • Member of The Expert Groups for the Guidelines of Steroid-induced Osteoporosis Prevention and Control in China .
  • Member of Chengdu city Medical Osteoporosis Committee attached to Chinese Medical Association.
  • Member of The Youth Working Committee of Sichuan Province Rheumatology Association.
  • Youth Committee of Sichuan Medical Association Internal Medicine special committee.

She has been trained for the clinical skill as the Postdoctoral scholar of Lupus center, Division of Rheumatology, School of Medicine of Johns Hopkins University (ranked first both for the comprehensive and Rheumatology academic levels for 21 years in U.S.A ), supervised by professor Michelle Petri, a lupus clinical experts. She has been the Postdoctoral Fellow in University of Maryland School of medicine, and PH.D fellow in Department of rheumatology, Renji Hospital , Shanghai Jiao Tong University School of Medicine (formerly Shanghai Second Medical University), supervised by Professor Yue ying Gu and Professor Nan Shen, as well as . Master and post-graduated in The Fourth Military Medical University, supervised by Professor Zhu Ping.

She has been engaging in clinical diagnosis and therapy, as well as research work in rheumatic diseases for 20 years with a wealth of clinical experience, especially on the field of systemic lupus erythematosus. Her basic research includes: the role of type I interferon/ induced gene in the pathogenesis of systemic lupus erythematosus, and their signal transduction pathway; activation of type I interferon pathway in the pathogenesis of lupus; acetylation of epigenetics in the pathogenesis of systemic lupus erythematosus; exploration of lupus genes and new molecular biomarkers as the targets. Now, she is also establishing a lupus cohort database and lupus professional websites, carrying on longitudinal cohort prospective clinical studies of the risk factors of lupus or other rheumatic diseases.

Recently, as the principle investigator, She won the supports from National Natural Science Foundation for 3 times; Sichuan Provincial Department of science and technology projects for 2 times, research funding more than 1 million RMB; participating a Key Project of the National Natural Science Foundation (more than 1. 6 million RMB). She has published 30 articles as the first author and corresponding author, such as 《J.Biol.Chem》, 《Cell signaling》, 《Arthritis Research & Therapy》, 《Journal of, Rheumatology》. She has written Chinese national Rheumatology textbooks published by People's Health Publishing House as the co-author. She won the outstanding teacher award of West China Hospital; the advanced research workers of West China Hospital; the secondary prize of English bilingual teaching competition in West China Hospital and School of Medicine, of Sichuan University..

She has been collaborating with the world well-known lupus experts, Professor Vinuesa Carola, a Fellow of the Academy of Sciences, Australian National University; Professor Michelle Petri, director of Lupus center, Johns Hopkins University; Professor Wakeland ,the director of the center of arthritis, Southwestern Medical Center USA, a prominent lupus gene founder; Nan Shen , director of Rhenji hospital, China.  

中华医学会全国风湿病学会中青年委员;国家自然基金评审委员会评审成员;全国医师定期考核专家委员会成员;中国激素诱导骨质疏松防治指南制定专家组成员。中华医学会成都市骨质疏松委员会委员。四川省医学会风湿病学会中青年委员;四川省医学会内科专委会中青年委员。成都市医学会骨质疏松专委会委员。美国约翰.霍普金斯大学风湿科狼疮中心(全美医学综合及风湿科排名第一)博士后、访问学者,师从世界著名狼疮专家Michelle Peter教授。美国马里兰大学医学院博士后。上海交通大学医学院(原上海二医大)仁济医院风湿科博士,师从著名狼疮专家顾越英教授和沈南教授。第四军医大学硕士,师从中华风湿病学会副主任委员朱平教授。

从事风湿病疾病诊治和科研工作20年,具有丰富的临床经验,掌握风湿疑难重症的诊治。长期从事风湿病的诊疗,尤其专注于红斑狼疮的诊疗和发病机制研究。2016年上半年有近60万风湿病患者访问个人专业医疗网站,每日有近3000患者访问,疗效和态度得到广大患者及同行好评。目前研究主要在:I型干扰素的基因在红斑狼疮发病机制中的功能作用、表达信号通路;I型干扰素通路活化在狼疮发病中的分子机制;乙酰化等表观遗传学参与在红斑狼疮等风湿病中的发病机制;探索新的狼疮致病基因和分子靶标。同时建立狼疮数据库和狼疮网站,纵向队列前瞻性临床研究,研究狼疮亚型,如狼疮脑病、狼疮肠系膜血管炎、狼疮肾炎等的疾病特点及危险因素。近年,撰写和/或作为项目负责人,获得国家自然基金面上项目3项、四川省科技厅科技支撑项目2项,科研经费超过100万元;参与国家自然基金重点项目1项(160余万元)。获得中国博士后基金二等奖1项、。在国内外重要期刊发表SCI等中英文风湿病文章30余篇,其中以第一作者和通讯作者发表在《J.Biol.Chem》、《Cell signaling》、《Arthritis Research & Therapy》、《Journal of Rheumatology》等D级期刊多篇。参与编写人民卫生出版社出版的《风湿病学》教材。2014年关于狼疮的研究工作被接收到美国风湿病年会(国际上学术水平规模最大的风湿病会议)做大会口头发言。多次在全国风湿病年会和中日韩中青年会议上进行大会发言;多次出访美国纽约、费城、加拿大温哥华等国家参加国际学术会议和交流。与国际著名狼疮研究专家澳大利亚国立大学科学院院士Carola Vinuesa教授、美国西南医学中心关节炎诊治中心主任、著名的狼疮基因发现者Wakeland教授、美国约翰霍普金斯狼疮中心Michelle Petri教授有深入合作关系。获得华西医院优秀教师奖,华西医院先进科研工作者、获得四川大学暨华西临床医学院中英文双语教学二等奖。