Systemic Lupus Erythematosus (SLE), more commonly known as lupus, is a chronic autoimmune disease with a broad range of clinical manifestations. It is characterised by acute and chronic inflammation in various tissues of the body including the skin, joints, kidneys, brain and other organs. The symptoms can range from relatively mild to life-threatening. In some, exposure to a trigger including certain medications can cause drug-induced lupus. These symptoms usually disappear once the person has ceased taking the medication.
Common Variable Immunodeficiency (CVID) is the most frequently diagnosed primary immunodeficiency disease, where a part of the immune system is absent or dysfunctional. In people with CVID, the B cells are affected. B cells are a specialised white blood cell in the immune system that protects the body from infection. When B cells mature, they produce proteins called antibodies (or immunoglobulins). These antibodies can recognise patterns on foreign particles (eg viruses) and form an important part of the immune response.